Spasmodic Dysphonia
An article written 2008
A long-standing disorder that finally found an effective treatment
By Dr. Redwan Kalash
Consultant in Laryngology, Voice, Swallowing Disorders, and Laryngeal Surgery
For decades, hundreds of thousands of people have suffered from this condition, living with a severely impaired voice throughout much of their lives. Whenever they sought medical advice, many were told that their voice problem was psychological. As a result, patients were often left without an explanation or an effective treatment.
Although spasmodic dysphonia was first described nearly a century and a half ago, effective treatment has only become available in recent decades. Even today, it remains a challenging diagnosis for many physicians, including some otolaryngologists.
What is Spasmodic Dysphonia?
Spasmodic dysphonia is a disorder of voice production. It is important to distinguish between voice and speech. Speech refers to the articulation of sounds, words, and sentences, while voice is the sound generated by the larynx (voice box). Disorders affecting speech are known as speech disorders, whereas disorders affecting voice are called voice disorders or dysphonias.
Many people have experienced temporary forms of dysphonia. During periods of stress, fear, or anxiety, the voice may become interrupted, strained, distorted, or even disappear completely despite a perfectly healthy larynx. This occurs because of abnormal muscle activity affecting the vocal folds.
However, other forms of dysphonia occur independently of emotional stress. Each type has its own underlying cause and requires a different treatment.
How is the Voice Produced?
The human voice is produced when the two true vocal folds come together and vibrate as air from the lungs passes between them during exhalation.
Any disease that interferes with the normal vibration of the vocal folds—such as vocal fold nodules, polyps, cysts, or vocal fold paralysis—can result in hoarseness or other voice abnormalities.
What Happens in Spasmodic Dysphonia?
In patients with spasmodic dysphonia, the vocal folds usually appear completely normal. There are no lesions, paralysis, or structural abnormalities. Consequently, conventional laryngeal examination may appear entirely normal.
The abnormal voice results from involuntary spasms affecting specific muscles that control the movement of the vocal folds during speech.
To diagnose the condition, videolaryngoscopy with detailed assessment of vocal fold motion is often required. In selected cases, laryngeal electromyography (LEMG) is used to identify the abnormal muscle activity and determine which laryngeal muscle is responsible.
Why Are Only the Laryngeal Muscles Affected?
The abnormal muscle contractions seen in spasmodic dysphonia belong to a group of neurological movement disorders known as dystonia.
When dystonia affects multiple muscle groups throughout the body, it may be associated with broader neurological diseases such as Parkinson's disease.
However, when dystonia affects only a single muscle or muscle group, it is called focal dystonia. Spasmodic dysphonia is a focal laryngeal dystonia in which one or more muscles controlling the vocal folds are affected.
Examples of other focal dystonias include:
Hemifacial spasm, characterized by repeated involuntary contractions affecting one side of the face.
Cervical dystonia (spasmodic torticollis), causing involuntary turning of the head to one side.
Blepharospasm, characterized by involuntary repetitive eyelid closure.
Spasmodic dysphonia, resulting from involuntary spasms of the muscles controlling the vocal folds.
How Does the Voice Sound?
Patients typically have a persistently strained, tight, and interrupted voice. The voice may sound as though someone is choking the speaker while talking or as though the speech is being forced out with great effort.
One of the interesting features of this disorder is that the voice often improves temporarily when the patient speaks in an unnatural voice, shouts, laughs, or sings.
Because the vocal folds appear normal during routine examination, many patients are incorrectly reassured that nothing is wrong with their larynx and are sometimes told that their symptoms are psychological.
Treatment of Spasmodic Dysphonia
Medication
Unfortunately, medications have little or no benefit in treating spasmodic dysphonia.
Voice Therapy
Voice therapy performed by a speech-language pathologist may provide limited improvement in selected patients but is generally insufficient as a sole treatment.
Surgery
Several surgical procedures have been developed and may improve voice quality in carefully selected patients.
The Most Effective Treatment
The current gold-standard treatment is the injection of botulinum toxin (Botox®) into the affected laryngeal muscle(s).
This is a simple office-based procedure performed under local anesthesia. A fine needle connected to a laryngeal electromyography (LEMG) system is used to accurately identify the target muscle. Once the needle reaches the affected muscle, botulinum toxin is injected.
The medication temporarily relaxes the overactive muscle, relieving the abnormal spasms and allowing the patient's voice to return to a much more natural quality.
For the majority of patients, botulinum toxin injection remains the treatment of choice and has dramatically improved the quality of life of individuals living with spasmodic